Plants produce hundreds of thousands of distinct small-molecule natural products, many of which are invaluable nutrients, commodity products, and therapeutics.
At the heart of the beautiful Okanagan Valley, Dang Group integrates biochemistry, chemistry, bioinformatics, and molecular genetics to elucidate and engineer the biosynthesis of valuable small molecules from medicinal plants. Our ultimate aim is to learn and to translate natural metabolism into innovative biotechnologies to meet the ever-increasing demands of high-value chemicals.
Noncovalent interactions play a central role in determining structure and reactivity throughout chemistry and physics. Our group develops and applies computational methods to understand this role.
We also computational chemistry techniques to study a wide variety of radical systems in chemistry, biochemistry and physics. Our current research focuses on quantum effects in enzymes that mediate radical rearrangement processes and on the potential for non-redox metal cations to act as a chemoprotective against radical damage through hydrogen atom transfer reactions.
The group aims to make impactful contributions to worldwide efforts in developing affordable clean energy. Our main focus is understanding the photophysical and photochemical processes that dictate efficiency in solar fuel producing systems. Our advanced time-resolved optical spectroscopy techniques give us the insights necessary to understand the influence of key physical and chemical parameters, and optimize material synthesis with strong rational.
The McNeil Research Group conducts chemistry education research by using our classrooms as our laboratories. We study the challenges associated with teaching and learning university-level chemistry and develop innovative learning strategies to address those challenges.
The Menard lab works at the interface between chemistry and biology. We use small molecules to study and manipulate biological systems. The group provides a multidisciplinary environment where students and researchers work together to develop new chemical and biophysical tools for the study of living systems.
PlantSMART investigates the chemicals produced by plants and how plant chemicals affect human health. Research themes include: chemistry of cannabis and other medicinal plants; plant chemistry for food security; chemistry of natural non-protein amino acids; chemical regulation of plant signalling behaviour; chemistry of plant responses to light.
Earth-abundant transition metal catalysts that operate under mild conditions will be required for valorization of renewable resources and more sustainable organic synthesis. The Smith research group has explored metal-mediated radical reactions based on reversible homolysis of chromium-alkyl bonds in well-defined organometallic complexes.
Enzymes are large macromolecules that serve as biological catalysts for an immense number of biochemical reactions. We explore how enzymes can serve as valuable tools for the synthesis of new drugs and other high commodity chemicals, and also lead to the treatment of diseases, including bacterial infections, cancer, and metabolic disorders.
We study the biophysics of cells at the single molecule and single cell levels. Our studies address fundamental cell biology questions that have many practical applications from smart DNA-based biomaterials to cell screening technology.
Our lab focuses on describing the chemistry of medicinal plants and bacteria to investigate the chemical differences between species and samples. This is used to discover biological activities, optimize natural health product formulation, identify adulterated products, and classify species by their chemistry.
A key objective of our lab is to combine capillary electrophoresis (CE) and mass spectrometry (MS) into a sensitive and high resolution method for glycan analysis. As a complement to the development of improved hyphenated analytical methods, we are also interested in devising more efficient sample preparation techniques. We also explore the roles played by glycans in diverse biological phenomena. Our lab members: investigate the effects of known chemical inhibitors of glycan processing enzymes; synthesize and test new inhibitors; devise assays to explore the functions of glycan biosynthetic enzymes; develop new methods for identifying glycan-binding proteins and their target.